Title :
Measurement of Strain and Strain Rate in Embryonic Chick Heart In Vivo Using Spectral Domain Optical Coherence Tomography
Author :
Peng Li ; Xin Yin ; Liang Shi ; Aiping Liu ; Rugonyi, S. ; Wang, R.K.
Author_Institution :
Dept. of Bioeng., Univ. of Washington, Seattle, WA, USA
Abstract :
The ability to measure in vivo strain and strain rate in embryonic chick heart is one of the key requirements for understanding the mechanisms of cardiac development. Due to its high temporal and spatial resolution as well as its fast imaging capability, optical coherence tomography (OCT) has the potential to reveal the complex myocardial activity in the living chick heart. We describe a method to evaluate the in vivo strain and strain rate of the myocardium through analyzing the periodic variation of the myocardial wall thickness calculated from real-time serial OCT images. The results demonstrate that OCT can be a useful tool to describe the biomechanical characteristics of the embryonic heart.
Keywords :
biomechanics; biomedical measurement; biomedical optical imaging; cardiology; optical tomography; physiological models; spectral analysis; strain measurement; biomechanical characteristics; complex myocardial activity; embryonic chick heart strain rate measurement; in-vivo analysis; myocardial wall thickness; real-time serial OCT images; spatial resolution; spectral domain optical coherence tomography; temporal resolution; Biomedical measurements; Heart; Imaging; In vivo; Myocardium; Strain; Three dimensional displays; Cardiac development; embryonic chick heart; medical and biological imaging; myocardial strain; optical coherence tomography; Animals; Chick Embryo; Compressive Strength; Computer Simulation; Elastic Modulus; Fetal Heart; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Models, Biological; Reproducibility of Results; Sensitivity and Specificity; Shear Strength; Stress, Mechanical; Tensile Strength; Tomography, Optical Coherence;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2011.2153851
