DocumentCode :
1518892
Title :
High-resolution absolute SPECT quantitation for I-131 distributions used in the treatment of lymphoma: a phantom study
Author :
Trotter, Dinko E González ; Jaszczak, Ronald J. ; Bowsher, James E. ; Akabani, Gamal ; Greer, Kim L.
Author_Institution :
GE Corp. Res. & Dev., Niskayuna, NY, USA
Volume :
48
Issue :
3
fYear :
2001
fDate :
6/1/2001 12:00:00 AM
Firstpage :
707
Lastpage :
714
Abstract :
Clinical lymphoma I-131 radioimmunotherapy (RIT) studies are underway at the authors´ institution. The effectiveness of treatment can be evaluated through accurate time-dependent three-dimensional (3-D) dosimetry calculations based on SPECT images. The authors compared the absolute quantitative SPECT performance of a high-resolution rotating parallel-hole collimator (RPHC) designed to minimize septal penetration with that of a traditional medium-energy parallel-hole collimator (MEPHC). The authors scanned a phantom consisting of four spheres having inner diameters of 2.2 and 2.8 cm and whose activity concentration ratios with respect to the surrounding medium were between 5:1 and 17:1. Images were reconstructed using the OSEM algorithm (10 subsets, 20 iterations) with spatial resolution modeling. Quantitation of the MEPHC SPECT images yielded a large over-estimation of the surrounding activity concentration (50%) due to septal penetration. Quantitation of the RPHC SPECT image yielded a surrounding medium activity concentration within 8% of the expected value, and the activity within the spheres was estimated to within 20% of their absolute expected values for the RPHC. The authors also investigated the effect of out of field-of-view (FOV) uncollimated gamma rays on SPECT quantitation. It is concluded that for the present quantitation application, the benefits of septal penetration suppression by the RPHC outweigh the increased image noise due to low count rate. These results point to the feasibility of using a large-FOV collimator based on the imaging principles of the RPHC for accurate clinical SPECT quantitation of I-131 RIT
Keywords :
cancer; image reconstruction; image resolution; iodine; medical image processing; radiation therapy; single photon emission computed tomography; 2.2 cm; 2.8 cm; I; I-131 distributions; accurate clinical SPECT quantitation; activity concentration ratios; high-resolution absolute SPECT quantitation; imaging principles; increased image noise; large-FOV collimator; low count rate; lymphoma treatment; medical diagnostic imaging; nuclear medicine; septal penetration suppression; spatial resolution modeling; Biomedical imaging; Collimators; Dosimetry; Image reconstruction; Imaging phantoms; Legged locomotion; Radioactive materials; Radiology; Single photon emission computed tomography; Spatial resolution;
fLanguage :
English
Journal_Title :
Nuclear Science, IEEE Transactions on
Publisher :
ieee
ISSN :
0018-9499
Type :
jour
DOI :
10.1109/23.940151
Filename :
940151
Link To Document :
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