Title :
One-pot synthesis and functionalisation of Fe2O3@CNH2 nanoparticles for imaging and therapy
Author :
Xiaofeng Li ; Jiabao Ding ; Xiaofeng Wang ; Kai Wei ; Jian Weng ; Jinan Wang
Author_Institution :
Coll. of Chem. & Chem. Eng., Xiamen Univ., Xiamen, China
Abstract :
The authors have prepared amine-modified Fe2O3@C nanoparticles with diameter of 20 nm by decomposing perchlorinated pyrene/Fe(NO3)3 mixture in the presence of ammonia in solvothermal conditions at 180°C for 48 h by a one-step process. NH3 is not only a cocatalyst of Fe(NO3)3 for decomposition of perchlorinated pyrene, but also the source of surface functionalisation group. The effect of synthesis conditions on shape and size of nanoparticles and characterisation of their structure and functionalisation group are investigated in this research. The amino group in the surface of core-shell nanoparticles can be further functionalised with polyethylene glycol and folic acid to improve their solubility in aqueous solution and target cancer cells. The applications of functionalised core-shell nanoparticles in magnetic resonance imaging and cancer thermal therapy are also investigated in this research.
Keywords :
biomedical MRI; biomedical materials; biothermics; cancer; carbon; catalysts; cellular biophysics; decomposition; iron compounds; nanofabrication; nanomedicine; nanoparticles; nitrogen compounds; particle size; patient treatment; polymers; solubility; Fe2O3-C-NH2; amine-modified nanoparticles; amino group; ammonia; aqueous solution; cancer cells; cancer thermal therapy; cocatalyst; decomposition; folic acid; functionalised core-shell nanoparticles; magnetic resonance imaging; nanoparticle size; one-pot synthesis; perchlorinated pyrene; polyethylene glycol; size 20 nm; solubility; solvothermal conditions; surface functionalisation group; temperature 180 degC; time 48 h;
Journal_Title :
Nanobiotechnology, IET
DOI :
10.1049/iet-nbt.2012.0015
