Optical coherence-gated imaging of biological tissues

Author

Pan, Y. ; Lankenou, E. ; Welzel, J. ; Birngruber, R. ; Engelhardt, R.

Author_Institution

Medizinisches Laserzentrum Lubeck, Germany

Volume

2

Issue

4

fYear

1996

fDate

12/1/1996 12:00:00 AM

Firstpage

1029

Lastpage

1034

Abstract

We present optical coherence-gated tomography (OCT) in turbid biological tissues. The fast OCT system that is used in this study is a single-mode fiber-optic interferometer with low-coherence light at 830 nm which can perform a cross-sectional image of 250-600 pixels in a few seconds. Preliminary results suggest that OCT can provide high-resolution imaging in low-scattering and high-scattering superficial tissues. In vitro imaging of porcine cornea after being coagulated with a laser shows that OCT is a promising tool for the evaluation of pathological structures in low-scattering tissue. This technique can also be used to diagnose disease in high-scattering tissues like bladder and living skin. In addition, 50 MHz ultrasound images and histological pictures are presented for comparison with OCT

Keywords

biomedical imaging; biomedical ultrasonics; eye; fibre optic sensors; image resolution; infrared imaging; light coherence; light interferometers; light scattering; optical tomography; skin; turbidity; 250 to 600 pixel; 50 MHz; 830 nm; biological tissues; bladder; cross-sectional image; disease diagnosis; fast OCT system; high-resolution imaging; high-scattering superficial tissues; histological pictures; in vitro imaging; laser coagulation; living skin; low-coherence light; low-scattering superficial tissues; optical coherence-gated imaging; optical coherence-gated tomography; pathological structures; porcine cornea; single-mode fiber-optic interferometer; turbid biological tissues; ultrasound images; Biological tissues; Biomedical optical imaging; Cornea; High-resolution imaging; In vitro; Optical imaging; Optical interferometry; Pixel; Tomography; Ultrasonic imaging;

fLanguage

English

Journal_Title

Selected Topics in Quantum Electronics, IEEE Journal of

Publisher

ieee

ISSN

1077-260X

Type

jour

DOI

10.1109/2944.577332

Filename

577332