Thermodynamics of new piroxicam derivatives in terahertz light

Author

Szczesniak-Siega, B. ; Fuglewicz, B. ; Nowak, K. ; Szlachetko, B. ; Sterczewski, L.A. ; Beziuk, G. ; Jarzab, P.P. ; Malinka, W. ; Baran, J. ; Drozd, M. ; Grzelczak, M.P. ; Hruszowiec, M. ; Plinska, S. ; Plinski, E.F.

Author_Institution

Wroclaw Med. Univ., Wrocław, Poland

fYear

2014

fDate

14-19 Sept. 2014

Firstpage

1

Lastpage

2

Abstract

Polymorphic conversion is a major concern of the pharmaceutical industry. Therefore, it is essential to characterize and quantify polymorphic forms of drugs. Vibrational spectroscopic techniques such as infrared, near-infrared, Raman and, most recently, terahertz pulsed spectroscopy have become popular for solid state analysis since they are fast and non-destructive and allow solid-state changes to be probed at the molecular level. We synthesized and investigated new derivatives of known anti-inflammatory drug piroxicam. One of the research method we applied is a THz spectroscopy presented in this paper.

Keywords

Raman spectra; drugs; infrared spectra; pharmaceutical industry; polymorphic transformations; terahertz spectroscopy; thermodynamics; Raman spectroscopy; antiinflammatory drug piroxicam; near-infrared spectroscopy; pharmaceutical industry; piroxicam derivatives; polymorphic conversion; polymorphic forms; solid state analysis; terahertz light; terahertz pulsed spectroscopy; thermodynamics; vibrational spectroscopy; Drugs; Powders; Spectroscopy; Temperature distribution; Temperature measurement; Thermodynamics;

fLanguage

English

Publisher

ieee

Conference_Titel

Infrared, Millimeter, and Terahertz waves (IRMMW-THz), 2014 39th International Conference on

Conference_Location

Tucson, AZ

Type

conf

DOI

10.1109/IRMMW-THz.2014.6956142

Filename

6956142