A new X-ray computed tomography system for laboratory mouse imaging

Author

Paulus, M.J. ; Sari-Sarraf, H. ; Gleason, S.S. ; Bobrek, M. ; Hicks, J.S. ; Johnson, D.K. ; Behel, J.K. ; Thompson, L.H. ; Allen, W.C.

Author_Institution

Oak Ridge Nat. Lab., TN, USA

Volume

46

Issue

3

fYear

1999

fDate

6/1/1999 12:00:00 AM

Firstpage

558

Lastpage

564

Abstract

Two versions of a new high-resolution X-ray computed tomography system are being developed to screen mutagenized mice in the Oak Ridge National Laboratory Mammalian Genetics Research Facility. The first prototype employs a single-pixel CdZnTe detector with a pinhole collimator operating in pulse counting mode. The second version employs a phosphor screen/CCD detector operating in current mode. The major system hardware includes a low-energy X-ray tube, two linear translation stages and a rotational stage. For the single-pixel detector, image resolution is determined by the step size of the detector stage; preliminary images have been acquired at 100 μm and 250 μm resolutions. The resolution of the phosphor screen detector is determined by the modulation transfer function of the phosphor screen; images with resolutions approaching 50 μm have been acquired. The system performance with the two detectors is described and recent images are presented

Keywords

CCD image sensors; computerised tomography; genetics; image resolution; optical transfer function; CCD detector; CdZnTe; current mode; detector stage step size; high-resolution X-ray computed tomography system; image resolution; laboratory mouse imaging; linear translation stages; low-energy X-ray tube; modulation transfer function; mutagenized mice; phosphor screen detector; pinhole collimator; pulse counting mode; rotational stage; single-pixel CdZnTe detector; system performance; Computed tomography; Detectors; Genetics; High-resolution imaging; Image resolution; Laboratories; Mice; Optical imaging; Phosphors; X-ray imaging;

fLanguage

English

Journal_Title

Nuclear Science, IEEE Transactions on

Publisher

ieee

ISSN

0018-9499

Type

jour

DOI

10.1109/23.775579

Filename

775579