Title :
Microwave Cancer Imaging Exploiting Magnetic Nanoparticles as Contrast Agent
Author :
Bellizzi, Gennaro ; Bucci, Ovidio M. ; Catapano, Ilaria
Author_Institution :
Dept. of Biomed., Electron. & Telecommun. Eng., Univ. of Naples Federico II, Naples, Italy
Abstract :
In this paper, a microwave technique for breast cancer imaging is presented. The approach is based on the use of magnetic nanoparticles as contrast agent to induce a nonnull magnetic contrast selectively localized within the tumor. This allows us to face cancer imaging as the reconstruction of a magnetic contrast from the corresponding scattered field. To extract, from the measured data the contribution due to the magnetic contrast, i.e., the signal meaningful for cancer imaging, the approach exploits the possibility of modulating the magnetic response of magnetic nanoparticles by means of a polarizing magnetic field. The achievable reconstruction capabilities and the robustness against uncertainties on the electric features of the surrounding electric scenario are assessed by means of numerical examples.
Keywords :
biological organs; cancer; gynaecology; image reconstruction; magnetic particles; medical image processing; microwave imaging; nanomedicine; nanoparticles; tumours; breast cancer imaging; electric features; image reconstruction; magnetic nanoparticles; microwave cancer imaging; microwave technique; nonnull magnetic contrast; polarizing magnetic field; tumors; Cancer; Magnetic cores; Magnetic field measurement; Magnetic resonance; Magnetic resonance imaging; Magnetic susceptibility; Breast cancer imaging; contrast agent; magnetic nanoparticles (MNPs); microwave imaging (MWI); Algorithms; Breast Neoplasms; Contrast Media; Diagnostic Imaging; Female; Humans; Image Processing, Computer-Assisted; Magnetic Fields; Magnetite Nanoparticles; Microwaves; Phantoms, Imaging; Signal Processing, Computer-Assisted;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2011.2158544