Inhibition of leukemia cell growth under magnetic fields of up to 8 T

Author

Ogiue-Ikeda, Mari ; Kotani, Hiroko ; Iwasaka, Masakazu ; Sato, Yuko ; Ueno, Shoogo

Author_Institution

Dept. of Biomed. Eng., Tokyo Univ., Japan

Volume

37

Issue

4

fYear

2001

fDate

7/1/2001 12:00:00 AM

Firstpage

2912

Lastpage

2914

Abstract

In the present study, we investigated whether strong magnetic fields affect the growth of leukemia cells. We used a horizontal type of superconducting magnet, which produced magnetic fields of up to 8 T at its center. Leukemia cells (TCC-S) were seeded in 40 ml flasks and incubated with and without magnetic field exposure for 5 days. TCC-S growth with magnetic field exposure was inhibited by 60~80% compared with TCC-S growth without magnetic field exposure, only with an initial cell density of 2×10⁴ cells/ml. To investigate the effect of air volume on leukemia cell growth, the volume of the medium was decreased. When the medium was exposed to a greater volume of air, an enhanced inhibition of leukemia cell growth was observed. The possible mechanism of the observed effects was a concentration change of dissolved oxygen in the cell medium. Redistribution of dissolved oxygen molecules might result in the lack of an essential amount of oxygen necessary for leukemia cell growth

Keywords

biological effects of fields; cancer; cellular effects of radiation; magnetic field effects; radiation therapy; 0 to 8 T; 5 day; TCC-S growth; air volume; concentration change; dissolved oxygen molecules; initial cell density; leukemia cell growth inhibition; magnetic fields; strong magnetic fields; superconducting magnet; Blood; Boring; Cancer; Cells (biology); Chemicals; Humans; Magnetic fields; Magnetic materials; Medical treatment; Superconducting magnets;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/20.951345

Filename

951345