Simulations of the behavior of synaptically driven neurons via time-invariant circuit models

Author

Storace, Marco ; Bove, Marco ; Grattarola, Massimo ; Parodi, Mauro

Author_Institution

Dept. of Biophys. & Electron. Eng., Genoa Univ., Italy

Volume

44

Issue

12

fYear

1997

Firstpage

1282

Lastpage

1287

Abstract

Describes computer simulations of the behavior of Hodgkin-Huxley neurons, based on a redefinition of membrane and synaptic connections as time-invariant circuit elements. Examples are given showing that this self-consistent equivalent circuit representation allows very efficient computer simulations and could facilitate the introduction of detailed biological neurons into formal neural networks.

Keywords

bioelectric phenomena; biology computing; biomembrane transport; digital simulation; equivalent circuits; neurophysiology; physiological models; Hodgkin-Huxley neurons; detailed biological neurons; electrophysiological behavior; formal neural networks; neuron membrane patch; self-consistent equivalent circuit representation; synaptic connections; synaptically driven neurons behavior simulation; time-invariant circuit elements; time-invariant circuit models; very efficient computer simulations; Biological system modeling; Biomembranes; Circuit simulation; Computational modeling; Computer simulation; Equivalent circuits; Neural networks; Neurons; Nonlinear equations; Voltage; Action Potentials; Animals; Cell Membrane; Computer Simulation; Humans; Models, Neurological; Neurons; Presynaptic Terminals; Synapses; Time Factors;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/10.650000

Filename

650000