An integrated circuit implementation of the Huxley sarcomere model

Author

Hudson, Tina A. ; Bragg, Julian A. ; Lin, David C. ; DeWeerth, Stephen P.

Author_Institution

Dept. of Electr. & Comput. Eng., Georgia Inst. of Technol., Atlanta, GA, USA

Volume

48

Issue

12

fYear

2001

fDate

12/1/2001 12:00:00 AM

Firstpage

1471

Lastpage

1479

Abstract

We have developed an integrated circuit to simulate the mechanical behavior demonstrated by sarcomeres found in skeletal muscle. The circuit is based upon the mathematical description of the attachment and detachment dynamics of cross-bridge populations and the force generated by the crossbridges, originally formulated by A. F. Huxley. We describe the process of designing the circuit model from the mathematical model, present the sarcomere circuit implementation, and demonstrate the transient and steady-state behaviors that the fabricated circuit produces. Comparison of our results to published mechanical behavior of skeletal muscle shows qualitative similarities. We conclude that the circuit muscle model exhibits the potential for real-time simulation of muscle contractions and could be used to give engineered systems muscle-like properties

Keywords

biomechanics; integrated circuits; muscle; physiological models; Huxley sarcomere model; attachment dynamics; crossbridge populations; detachment dynamics; engineered systems; force generation; integrated circuit implementation; mechanical behavior simulation; muscle contractions; muscle-like properties; neuromorphic engineering; real-time simulation; Actuators; Biological system modeling; Biomedical engineering; Integrated circuit modeling; Laboratories; Mathematical model; Muscles; Neural engineering; Physiology; Power system modeling;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/10.966606

Filename

966606