Evaluation of the TierPET system

Author

Weber, S. ; Herzog, H. ; Cremer, M. ; Engels, R. ; Hamacher, K. ; Kehren, E. ; Muehlensiepen, H. ; Ploux, L. ; Reinartz, R. ; Reinhart, P. ; Rongen, E. ; Sonnenberg, E. ; Coenen, H.H. ; Halling, H.

Author_Institution

Forschungszentrum Julich GmbH, Germany

Volume

46

Issue

4

fYear

1999

fDate

8/1/1999 12:00:00 AM

Firstpage

1177

Lastpage

1183

Abstract

The TierPET system, a high resolution 3D positron emission tomograph, has been developed to perform small animal positron emission tomography (PET) studies. High resolution PET opens the possibility to perform animal trials without the need for vivisection. This reduces the number of animals and the costs for such experiments, for example concerning the development of new radiopharmaceuticals. The scanner uses two orthogonal pairs of detectors consisting of arrays of small individual YAP crystals coupled to position sensitive photomultipliers. The center-detector distance may be varied to improve either sensitivity or spatial resolution. The spatial resolution of the scanner is 2.1 mm

Keywords

biological techniques; biomedical equipment; image resolution; photomultipliers; positron emission tomography; 2.1 mm; TierPET system evaluation; YAP; YAlO3; animal trials; high resolution 3D positron emission tomograph; medical instrumentation; new radiopharmaceuticals development; orthogonal detectors pairs; position sensitive photomultipliers; sensitivity; small animal positron emission tomography studies; small individual YAP crystals arrays; spatial resolution; vivisection; Animals; Costs; Detectors; Drugs; Optical scattering; Photomultipliers; Photonic crystals; Positron emission tomography; Spatial resolution; Transmission line matrix methods;

fLanguage

English

Journal_Title

Nuclear Science, IEEE Transactions on

Publisher

ieee

ISSN

0018-9499

Type

jour

DOI

10.1109/23.790853

Filename

790853