Title :
Phase contrast MRI for discriminating brain microbleed in a multicentre clinical study
Author :
Kaaouana, Takoua ; de Rochefort, Ludovic ; Samaille, Thomas ; Thierry, Nathalie ; Dufouil, Carole ; Delmaire, Christine ; Dormont, Didier ; Chupin, Marie
Author_Institution :
ICM, UPMC Univ. Paris 06, Paris, France
Abstract :
Brain microbleeds (BMBs) have emerged as a new imaging marker of small vessel diseases and they may play a crucial role in degenerative pathology such as Alzheimer´s disease. Composed of hemosiderin, BMBs can be efficiently detected with MRI sequences sensitive to magnetic susceptibility (e.g. gradient recalled echo T2*W images). Nevertheless, that identification remains challenging because of confounding structures and lesions. Most T2*W hyposignals result from local magnetic field inhomogeneity and can be identified either as BMBs, veins or brain micro-calcifications (BMCs). Differential diagnosis of BMBs and BMCs usually requires an additional CT scan. Quantitative susceptibility mapping techniques were proposed to discriminate between diamagnetic and paramagnetic structures, but they require a full 3D dataset and complex post-processing. Here, we introduce a fast 2D phase processing technique including unwrapping and harmonic filtering. We demonstrate its applicability and robustness on multicenter data acquired in standardized clinical setting to discriminate between paramagnetic BMBs and diamagnetic BMCs.
Keywords :
biomagnetism; biomedical MRI; blood; blood vessels; brain; diamagnetism; diseases; filtering theory; image sequences; magnetic susceptibility; medical image processing; paramagnetism; 2D phase processing technique; Alzheimer disease; MRI sequences; T2*W hyposignals; brain microcalcifications; complex post-processing; computerised tomography scan; confounding structures; degenerative pathology; diamagnetic structures; differential diagnosis; discriminating brain microbleed; full 3D dataset; gradient recalled echo T2*W images; harmonic filtering; hemosiderin; imaging marker; lesions; local magnetic field inhomogeneity; magnetic susceptibility; multicenter data acquisition; multicentre clinical study; paramagnetic structures; phase contrast MRI; quantitative susceptibility mapping techniques; small vessel diseases; standardized clinical setting; unwrapping filtering; Filtering; Harmonic analysis; Magnetic resonance imaging; Magnetic susceptibility; Power harmonic filters; Three-dimensional displays; calcification; dipolar pattern; harmonic filter; microbleeds; phase processing; susceptibility;
Conference_Titel :
Advanced Technologies for Signal and Image Processing (ATSIP), 2014 1st International Conference on
Conference_Location :
Sousse
DOI :
10.1109/ATSIP.2014.6834619