Automatic Ca2+ Sparks Detection System

This paper proposes a fully automatic approach for Ca²⁺ spark events detection in confocal image system. This system automatically detects the region of interest and separates it from the background, automatically finds the optimal thresholds for Ca²⁺ sparks detection, and takes advantage of the correlation between two consecutive frames in detecting the Ca²⁺ sparks. The experiment results show that the proposed method is very promising. Compared to the conventional system (proposed by Cheng et. al and later improved by Chun et. al), the preliminary experimental results show that the proposed system can achieve higher accuracy rate without compromising false alarm rate.