Accurate localization of lung tumor based on deformable registration

In the tumor diagnose and radiation therapy system, it is significant and essential to obtain the accurate tumor characteristics. However, some processing of the medical images like registration, may bring small deformation to the test tumor, and hence affect the results of diagnose and treatment. In order to maintain the shape and size of the lung tumor and at the same time, obtain the accurate localization of tumor, a method to avoid the small deformation between the template and the test volume after their registration is proposed in this paper. Both multi-modality and mono-modality multi-resolution registrations are realized and experiment results obtained using ITK software show that with the proposed method, more accurate localization of the lung tumor with the original size and shape after registration can be obtained in order to give the technical support for the doctors and scientists.