Title :
An acoustic plate mode device for biosensor applications
Author :
Andle, J.C. ; Vetelino, J.F. ; Lade, M.W. ; McAllister, D.J.
Author_Institution :
Dept. of Electr. Eng., Maine Univ., Orono, ME, USA
Abstract :
Experimental data are presented which show that the dual delay line interferometer consisting of SH-APM (shear horizontal acoustic plate mode) devices is a sensitive analytical tool potentially capable of detecting subnanogram per millimeter quantities of a specific DNA sequence without interference from thermal drift or nonspecific DNA sequences. The APM biosensor was tested with DNA polymers and showed a measurable response at the nanogram level per millimeter of solution. The biosensor is reusable and qualitatively reproducible.<>
Keywords :
DNA; acoustic wave interferometers; biosensors; surface acoustic wave devices; ultrasonic delay lines; DNA sequence; acoustic plate mode device; biosensor applications; dual delay line interferometer; qualitatively reproducible; reusable; shear horizontal acoustic plate mode; subnanogram per millimeter quantities; Acoustic applications; Acoustic devices; Acoustic signal detection; Acoustic testing; Biosensors; DNA; Delay lines; Interference; Millimeter wave devices; Sequences;
Conference_Titel :
Solid-State Sensors and Actuators, 1991. Digest of Technical Papers, TRANSDUCERS '91., 1991 International Conference on
Conference_Location :
San Francisco, CA, USA
Print_ISBN :
0-87942-585-7
DOI :
10.1109/SENSOR.1991.148917
