Biomimetic coating of apatite/collagen composite on Poly L-lactic Acid facilitates cell seeding

Author

Chen, Yun ; Mak, Arthur F T ; Wang, Min ; Li, Jiashen

Author_Institution

Jockey Club Rehabilitation Eng. Center, Hong Kong Polytech. Univ.

fYear

2006

Firstpage

4087

Lastpage

4090

Abstract

Collagen and apatite were co-precipitated as a composite coating on poly L-lactic acid (PLLA) in an accelerated biomimetic process. The coating formed on PLLA films after 24 hours incubation was characterized. Saos-2 osteoblast-like cells were used to evaluate the cell seeding on this biomimetic composite coating. It was shown that cell seeding on PLLA films with the composite coating was greatly improved. PLLA coated with submicron collagen fibrils and submicron apatite particulates can facilitate bone tissue engineering

Keywords

bioceramics; biomimetics; bone; calcium compounds; cellular biophysics; coatings; composite materials; molecular biophysics; polymer films; proteins; tissue engineering; 24 hour; CaPO₄; PLLA films; Saos-2 osteoblast-like cells; apatite/collagen composite; biomimetic coating; bone tissue engineering; cell seeding; coprecipitation; poly L-lactic acid; Acceleration; Biomimetics; Bone tissue; Chemical analysis; Coatings; Gold; Plastic films; Polymer films; Spectroscopy; X-ray diffraction;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the

Conference_Location

Shanghai

Print_ISBN

0-7803-8741-4

Type

conf

DOI

10.1109/IEMBS.2005.1615361

Filename

1615361