Study of HIV Variability based on Genomic Signal Analysis of Protease and Reverse Transcriptase Genes

Author

Cristea, P.D. ; Tuduce, Rodica Aurora ; Otelea, D.

Author_Institution

Biomed. Eng. Center, Univ. Politehnica of Bucharest

fYear

2006

Firstpage

4795

Lastpage

4798

Abstract

The conversion of genomic sequences into digital genomic signals offers the possibility to use signal processing methods for the analysis of genomic information. The study of genomic signals reveals local and global features of chromosomes that would be difficult to identify by using only the symbolic representation used in genomic data bases. The paper presents a study of the HIV protease (PR) and reverse transcriptase (RT) genes by combining standard nucleotide sequence analysis with IT techniques based on the genomic signal approach. Cumulated and unwrapped phases of genomic signals are analyzed to characterize the variability of clade F HIV-1 strains isolated in Romania

Keywords

cellular biophysics; enzymes; genetics; medical signal processing; microorganisms; molecular biophysics; HIV variability; chromosomes; clade F HIV-1 strains; digital genomic signals; genomic sequences; genomic signal analysis; nucleotide sequence analysis; protease transcriptase genes; reverse transcriptase genes; signal processing; Bioinformatics; Biological cells; Capacitive sensors; DNA; Genomics; Human immunodeficiency virus; Proteins; Sequences; Signal analysis; Signal processing;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the

Conference_Location

Shanghai

Print_ISBN

0-7803-8741-4

Type

conf

DOI

10.1109/IEMBS.2005.1615544

Filename

1615544