Title :
Study on a Nanoparticle System for Buccal Delivery of Insulin
Author :
Luo, Yong ; Xu, Huibi ; Huang, Kaixun ; Gao, Zhonghong ; Peng, Hong ; Sheng, Xiqun
Author_Institution :
Dept. of Chem., Huazhong Univ. of Sci. & Technol., Wuhan
Abstract :
In this paper, a nanoparticle system of insulin (NSI) was prepared for buccal transmucosal delivery of insulin. The average size of the suspending particles was 67.5 nm, and a possible microstructure of the nanoparticles in the system was proposed. The transmucosal ability of insulin was evaluated in rabbits from the views of the hypoglycaemic rate and pharmacokinetics. The average bioavailability of NSI by buccal delivery versus subcutaneous injection is 18.3%. These results indicate that the studied nanoparticle system may be promising vehicles for the buccal delivery of insulin
Keywords :
drug delivery systems; nanoparticles; nanotechnology; buccal transmucosal insulin delivery; hypoglycaemic rate; microstructure; nanoparticle system; pharmacokinetics; rabbits; Biochemistry; Biological materials; Chemical technology; Chemistry; Drug delivery; Humans; Insulin; Nanobioscience; Pharmaceuticals; Vehicles;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1615556
