The Study on Bionic Olfactory Neurochip Based on Light-addressable Potentiometric Sensor

Olfactory system can distinguish thousands of odors. In order to utilize biological olfactory neurons as sensitive material of electronic nose, this article reports an olfactory neurochip as real bionic technique for odorants detection. Effective cultures of olfactory receptor neurons and olfactory bulb cells on the chip have been achieved. Using light-addressable potentiometric sensor (LAPS) as sensing chip to monitor extracellular potential of the neurons, we tested the response under stimulations of the odorants or neurotransmitters, such as acetic acid and glutamic acid. The results demonstrate that this kind of the LAPS and olfactory neurons hybrid system is sensitive to environmental changes, which has potential to be used as a novel bioelectrical nose for detecting odors