DocumentCode
1578029
Title
Clinical usefulness of amifostine (YM-08310, WR-2721) as a radioprotective agent
Author
Takahashi, Iku ; Niibe, Hideo ; Mitsuhashi, Norio ; Nagai, Teruo
Author_Institution
Dept. of Radiol., Gunma Univ. Sch. of Med., Maebashi, Japan
fYear
1988
Firstpage
1042
Abstract
Radioprotective effects of amifostine were established for acute radiation injury using mucositis in the oral cavity and diarrhea as an index. For chronic radiation injury, radioprotective effects were suggested by the changes in the uptake of Ga-67 citrate in the irradiated salivary glands. Slight adverse reactions appeared, and radioprotective effects on the tumor tissue were not apparent. These results suggested that amifostine can be used as a radioprotective agent in clinical use.<>
Keywords
radiation protection; WR-2721; YM-08310; acute radiation injury; amifostine; chronic radiation injury; diarrhea; irradiated salivary glands; mucositis; oral cavity; radioprotective agent;
fLanguage
English
Publisher
ieee
Conference_Titel
Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE
Conference_Location
New Orleans, LA, USA
Print_ISBN
0-7803-0785-2
Type
conf
DOI
10.1109/IEMBS.1988.95369
Filename
95369
Link To Document