Title :
A Novel Remote Controlled Capsule for Human Drug Absorption studies
Author :
Pi Xitian ; Zheng Xiaolin ; Peng Chenglin ; Hou Wenshen ; Liu Hongying
Author_Institution :
Key Lab for Biomechanics & Tissue Eng. of the State Ministry of Educ., Chongqing Univ.
Abstract :
Remote controlled capsule (RCC) is a new method to realize non-invasive drug delivery to the selected sites of human gastro-intestinal (GI) tract. With RCC, human drug absorption (HDA) studies are taken easily to obtain data on the intestinal absorption of a drug in humans. In this paper, a new RCC system has been designed based on MEMS technology to provide for the delivery of a wide range of different drug formulations, for example, solution, powder and granulate, into any region of the gut. A magnetic marker monitoring (MMM) system was developed to monitor the location of the capsule inside the gut. A novel method to indicating the drug release, called as indicating system based on abrupt movement of marker (ISAMM), was proposed in this study. High reliability of the RCC system has been proved by animal experiments
Keywords :
bioMEMS; biomagnetism; drug delivery systems; medical control systems; telecontrol; MEMS technology; abrupt marker movement; human drug absorption; human gastro-intestinal tract; indicating system; magnetic marker monitoring system; noninvasive drug delivery; remote controlled capsule; Absorption; Biological control systems; Biomedical engineering; Drugs; Humans;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1615615
