Photo-Triggering of the Membrane Gates in Photo-Responsive Polymer for Drug Release

Author

Lee, Jae Kyoo ; Lee, Hoeun ; Jang, Eunje ; Lee, Sin-Doo ; Kim, Sung June

Author_Institution

Interdisciplinary Program of Biomed. Eng., Seoul Nat. Univ.

fYear

2005

fDate

6/27/1905 12:00:00 AM

Firstpage

5069

Lastpage

5072

Abstract

The use of light stimulus for triggering drug is a promising method for accurate drug delivery. A new approach using azopolymer membrane and laser holography was investigated for developing light-triggering drug delivery system. Polymeric drug delivery system was prepared by covering azopolymer membrane on a drug agent. Holographic laser interference generated surface relief grating pattern on the azopolymer surface. The widths and depths of gates on the polymer membrane were easily modified by adjusting incident angle and irradiation time. Ar laser made the polymeric membrane permeable to the drug agent and release it in a solution. This result indicated that the azopolymer and laser holography would provide a strong foundation for the light-triggering drug delivery system

Keywords

drug delivery systems; holography; laser applications in medicine; laser beam effects; membranes; polymers; azopolymer membrane; drug release; laser holography; light stimulus; membrane gates; photoresponsive polymer; phototriggering; polymeric drug delivery system; surface relief grating pattern; Biomedical engineering; Biomembranes; Drug delivery; Gratings; Holography; Interference; Optical polarization; Optical surface waves; Polymer films; Surface emitting lasers;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the

Conference_Location

Shanghai

Print_ISBN

0-7803-8741-4

Type

conf

DOI

10.1109/IEMBS.2005.1615616

Filename

1615616