Title :
Optical fiber technologies for in-vivo light delivery and optogenetics
Author :
Sileo, Leonardo ; Pisanello, Marco ; Della Patria, Andrea ; Emhara, Mohamed S. ; Pisanello, Ferruccio ; De Vittorio, Massimo
Author_Institution :
Center for Bio-Mol. Nanotechnol., Ist. Italiano di Tecnol., Lecce, Italy
Abstract :
In optogenetics, light-sensitive proteins are genetically targeted into specific classes of neurons in living animal models (typically mice), making possible to control their neural activity by means of visible light delivered into the brain tissue. In this paper, recent advances on techniques for in-vivo optical stimulation and inhibition of neuronal activity in optogenetic experiments are reported, with particular emphasis on new a new generation of fiber-optic technologies.
Keywords :
biological effects of optical radiation; biological techniques; biomolecular effects of radiation; neurophysiology; optical fibres; proteins; brain tissue; fiber optic technologies; in vivo light delivery; in vivo optical stimulation; light sensitive proteins; living animal models; neural activity control; neuronal activity inhibition; neurons; optical fiber technologies; optogenetic experiments; optogenetics; visible light delivery; Biomedical optical imaging; In vivo; Integrated optics; Neurons; Optical fiber devices; Optical fibers; light delivery; optical fibers; optogenetics; tapered fibers;
Conference_Titel :
Transparent Optical Networks (ICTON), 2015 17th International Conference on
Conference_Location :
Budapest
DOI :
10.1109/ICTON.2015.7193312
