Optical fiber technologies for in-vivo light delivery and optogenetics

Author

Sileo, Leonardo ; Pisanello, Marco ; Della Patria, Andrea ; Emhara, Mohamed S. ; Pisanello, Ferruccio ; De Vittorio, Massimo

Author_Institution

Center for Bio-Mol. Nanotechnol., Ist. Italiano di Tecnol., Lecce, Italy

fYear

2015

Firstpage

1

Lastpage

5

Abstract

In optogenetics, light-sensitive proteins are genetically targeted into specific classes of neurons in living animal models (typically mice), making possible to control their neural activity by means of visible light delivered into the brain tissue. In this paper, recent advances on techniques for in-vivo optical stimulation and inhibition of neuronal activity in optogenetic experiments are reported, with particular emphasis on new a new generation of fiber-optic technologies.

Keywords

biological effects of optical radiation; biological techniques; biomolecular effects of radiation; neurophysiology; optical fibres; proteins; brain tissue; fiber optic technologies; in vivo light delivery; in vivo optical stimulation; light sensitive proteins; living animal models; neural activity control; neuronal activity inhibition; neurons; optical fiber technologies; optogenetic experiments; optogenetics; visible light delivery; Biomedical optical imaging; In vivo; Integrated optics; Neurons; Optical fiber devices; Optical fibers; light delivery; optical fibers; optogenetics; tapered fibers;

fLanguage

English

Publisher

ieee

Conference_Titel

Transparent Optical Networks (ICTON), 2015 17th International Conference on

Conference_Location

Budapest

Type

conf

DOI

10.1109/ICTON.2015.7193312

Filename

7193312