DocumentCode :
158676
Title :
Mathematical study of the global dynamics of a concave gene expression model
Author :
Belgacem, Ismail ; Gouze, Jean-Luc
Author_Institution :
INRIA, BIOCORE Project-Team, Sophia Antipolis, France
fYear :
2014
fDate :
16-19 June 2014
Firstpage :
1341
Lastpage :
1346
Abstract :
We describe in this paper the global dynamical behavior of a mathematical model of expression of polymerase in bacteria. This model is given by a differential system and algebraic equations. We use some tools from monotone systems theory with concavity of nonlinearities to obtain a global qualitative result: either the trivial equilibrium is globally stable, either there exists a unique positive equilibrium which is globally stable in the positive orthant. The same result holds for a class of qualitatively defined functions. Some generalizations of this result are given.
Keywords :
cellular biophysics; differential algebraic equations; enzymes; genetics; microorganisms; molecular biophysics; algebraic equations; bacteria; concave gene expression model; differential system; global dynamical behavior; mathematical model; monotone system theory; nonlinearity concavity; polymerase expression; trivial equilibrium; unique positive equilibrium; Biological system modeling; Equations; Jacobian matrices; Mathematical model; Polymers; RNA; Stability analysis;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Control and Automation (MED), 2014 22nd Mediterranean Conference of
Conference_Location :
Palermo
Print_ISBN :
978-1-4799-5900-6
Type :
conf
DOI :
10.1109/MED.2014.6961562
Filename :
6961562
Link To Document :
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