Title :
Regional wall motion analysis: an important tool to study pharmacologic agents in the absence of systemic effects
Author :
van Eyll, C. ; Stoleru, L. ; Hayashida, W. ; Bouvy, T. ; Hanet, C. ; Van Mechelen, H. ; Charlier, A.A. ; Rousseau, MF ; Pouleur, H.
Author_Institution :
Sch. of Med., Louvain Univ., Brussels, Belgium
Abstract :
The authors present a method of quantitative regional wall motion analysis able to provide a precise evaluation of the effects of an intracoronary infused drug on the systolic and diastolic myocardial function in patients with aortic stenosis. The computation of the changes in regional areas, of regional peak filling rate, of an index of regional chamber stiffness and of the changes in regional area during isovolumic relaxation revealed a selective improvement of myocardial diastolic function in the perfused territory. As this improvement remained undetected when the global indices of left ventricular function were examined, it is concluded that regional wall motion analysis is indispensable to correctly assess the effects of intracoronary drug administration
Keywords :
biomechanics; cardiology; aortic stenosis patients; diastolic function; intracoronary infused drug; isovolumic relaxation; perfused tissue; pharmacologic agents; quantitative regional wall motion analysis; regional area; regional chamber stiffness; regional peak filling rate; systemic effects; systolic function; Arteries; Biochemistry; Clinical trials; Design methodology; Drugs; Filling; Inhibitors; Motion analysis; Myocardium; Performance analysis;
Conference_Titel :
Computers in Cardiology 1992, Proceedings of
Conference_Location :
Durham, NC
Print_ISBN :
0-8186-3552-5
DOI :
10.1109/CIC.1992.269529
