An integrated circuit for tissue impedance measure

Author

Yufera, Alberto ; Leger, G. ; Rodríguez-Villegas, E.O. ; Muñoz, J.M. ; Rueda, A. ; Ivorra, A. ; Gomez, R. ; Noguera, N. ; Aguiló, J.

Author_Institution

Centro Nacional de Microelectron., Instituto de Microelectron. de Sevilla, Seville, Spain

fYear

2002

fDate

6/24/1905 12:00:00 AM

Firstpage

88

Lastpage

93

Abstract

In this paper, the design of as integrated circuit (IC) for the measurement of tissue impedance is presented. The chip is intended to be used in monitoring biomedical parameters in living bodies. Tissue impedance is one of these parameters which allows ischemia monitoring. The designed IC is used in a four-electrode based set-up in order to minimize the effect of electrode-electrolyte interface impedance. A needle shaped probe which contains the four electrodes for the impedance measurement and ICs required for excitation and measurement purpose have been designed, fabricated and tested in-vivo. The IC has been fabricated in a 0.8 μm CMOS process, working at 3 V of power supply. Test results have shown the circuit feasibility

Keywords

CMOS integrated circuits; bioelectric phenomena; biological tissues; biomedical electrodes; biomedical electronics; biomedical measurement; demodulation; electric impedance measurement; 3 V; CMOS process; biomedical parameters; circuit model extraction; electrode-electrolyte interface impedance; four-electrode based set-up; integrated circuit design; ischemia monitoring; living bodies; needle shaped probe; passivation layer; tissue impedance measurement; two-phase reference coherent demodulation; Biomedical measurements; Biomedical monitoring; Circuit testing; Condition monitoring; Impedance measurement; Integrated circuit measurements; Ischemic pain; Needles; Probes; Semiconductor device measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Microtechnologies in Medicine & Biology 2nd Annual International IEEE-EMB Special Topic Conference on

Conference_Location

Madison, WI

Print_ISBN

0-7803-7480-0

Type

conf

DOI

10.1109/MMB.2002.1002271

Filename

1002271