A Quantitative Description of Conductance of Human Stratum Corneum Caused by Pulse Electrical Field

It is expounded the properties of conductance changes of the stratum corneum (SC) under the electric pulse field. It is considered that conductance for SC is determined by activation and inactivation factors. With the diffusion chamber as system, and the SC from cadaver as the object, we studied the behavior of the conductance change under the electric pulse field. The results show that theoretical curves of conductance on SC are fitted very well with the data from these experiments. So the conclusion is that these parameters of activation factor and inactivation factor (m⁰, m_infin, tau_m, h₀, h_infin, and tau_h ) are believed to be a very important significance for the analysis of drug transport through skin