Title :
Application of Microdialysis Technique in the Traditional Chinese Medicine
Author :
Zhang, Shaomin ; Zeng, Xianghui ; Xu, Xiaohong ; Zheng, Xiaoxiang
Author_Institution :
Key Laboratory of Biomed. Eng. of Ministry of Educ., Zhejiang Univ., Hangzhou
Abstract :
The concentration of extracellular neurotransmitters can be dynamically measured by in vivo microdialysis. This technique can apply to quantitatively evaluating the beneficial effects of traditional Chinese medicine (TCM). In the present study, the protective effects of Puerarin (Pur) on cerebral injuries evoked by ischemia/reperfusion was supported by a decrease of extracellular amino acids, especially glutamate (Glu), which were monitored by microdialysis combined with HPLC throughout the experiments. It suggested that, in addition to being a versatile and practical method in neuroscience, the microdialysis technique would play an important role in assessing and screening the effects of TCM
Keywords :
biomedical measurement; brain; cellular biophysics; chromatography; neurophysiology; patient diagnosis; patient treatment; HPLC; Puerarin; cerebral injuries; extracellular amino acids; extracellular neurotransmitters; glutamate; ischemia; microdialysis; neuroscience; reperfusion; traditional Chinese medicine; Animals; Biomedical engineering; Carotid arteries; Extracellular; In vivo; Independent component analysis; Laboratories; Monitoring; Neurotransmitters; Surgery; Microdialysis; Neurotransmitter; Traditional Chinese Medicine;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1616303
