A Novel PBPK/PD Model with Automatic Nervous System in Anesthesia

In terms of the characteristic of anesthetic operation, this paper propose new physiologically based pharmacokinetics/ pharmacodynamics (PBPK/PD) model that focus on the important role of autonomic nervous system (ANS) more. Automatic nervous system that is divided into the sympathetic nervous system and the parasympathetic nervous system, at the same time, is the important target of drug effect in anesthesia. Consequently, not only does the action levels of automatic nervous system indicator the anesthesia state, but feed back altering the physiological state parameters of pharmacokinetics, which being one crucial reason of time-variant and nonlinear drug effect. However, the recent PBPK modeling and simulation strategy only estimate specific absorption, distribution, metabolism and excretion (ADME) parameters but consider no modulation result of automatic nervous system any longer. So far, in order to avoid over-interpreted data from mathematical models and to take more consideration of clinical significance, the PBPK/PD model with automatic nervous system presented is helpful to make clearer relationship between PK and PD, that between sophisticated of model and real physiological phenomenon in anesthesia than before