High Resolution 3D Imaging of Lung Tissue using Structured Light Microscopy

Author

Kvistedal, Y.A. ; Tawhai, M. ; Hunter, P. ; Nielsen, P.M.F.

Author_Institution

Inst. of Bioeng., Auckland Univ.

fYear

2006

Firstpage

193

Lastpage

195

Abstract

A 3D reconstruction microscope has been built in order to investigate the structural details of the airway tree and the vasculature of mouse lungs. The objective is to create an anatomically correct finite element model of a mouse lung in order to validate results from simulations obtained using an existing model of the human lung. The 3D reconstruction microscope consists of a fully automated scanning stage, a vibratome and a structured light optical microscope. Structured light microscopy is a new approach to optical sectioning of tissue and offers several advantages over confocal microscopy

Keywords

biomedical optical imaging; finite element analysis; lung; optical microscopy; 3D reconstruction microscope; airway tree; anatomically correct finite element model; fully automated scanning stage; high resolution 3D imaging; lung tissue; mouse; optical sectioning; structured light optical microscope; vasculature; vibratome; Biomedical engineering; Biomedical optical imaging; High-resolution imaging; Humans; Image reconstruction; Image resolution; Lungs; Mice; Optical imaging; Optical microscopy;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the

Conference_Location

Shanghai

Print_ISBN

0-7803-8741-4

Type

conf

DOI

10.1109/IEMBS.2005.1616375

Filename

1616375