Pulmonary and Cardiovascular Integrated Model Controlled with Oxygen Consumption

We built a pulmonary and cardiovascular integrated model which is driven by O₂ consumption. The integrated model consists of a pulmonary model, a cardiovascular model, a gas exchange model, a respiratory control system model and a cardiovascular control model. To verify the integrated model, we calculated ventilations and cardiac outputs in different O₂ consumptions and compared the results with literature values. The literature values are experimental data of healthy men during rest and exercise on a bicycle ergometer. Additionally we checked that the calculated O₂ and CO₂ transfer rate between blood and alveolar region are consistent with given O₂ consumption and CO₂ production