Title :
Prolongation of refractoriness by trains of subthreshold high-frequency stimuli: a simulation study
Author :
Saiz, J. ; Ferrero, J.M., Jr. ; Chorro, J. ; Monserrat, M. ; Torres, V. ; Ferrero, J.M. ; Thakor, N.V.
Author_Institution :
Univ. Politecnica de Valencia, Spain
Abstract :
The effect of subthreshold high-frequency stimuli (TSc) on the prolongation of the refractory period (ERP) was studied using a computer model of a segment of ventricular tissue. The electrical behavior of each cell has been simulated using the Luo and Rudy phase II model. Trains of subthreshold high-frequency stimuli, at different frequencies, were applied between two suprathreshold pulses S1 and S2. The authors´ results show that when the TSc frequencies increases the ERP is elevated. The results also suggest that the delaying of recovery from inactivation of the fast INa current may be partially responsible for the ERP prolongation
Keywords :
bioelectric phenomena; cardiology; cellular biophysics; digital simulation; medical computing; physiological models; Luo-Rudy phase II model; Na; cardiac electrophysiology; cellular electrical behavior; computer model; fast INa current; refractoriness prolongation; simulation study; subthreshold high-frequency stimuli trains; ventricular tissue segment; Application software; Biomedical computing; Biomedical engineering; Cardiology; Computer simulation; Delay; Enterprise resource planning; Frequency; Hospitals; Medical simulation;
Conference_Titel :
Computers in Cardiology 1997
Conference_Location :
Lund
Print_ISBN :
0-7803-4445-6
DOI :
10.1109/CIC.1997.648149
