Site-specific bio-functionalization of surfaces by means of metal nanostructures

Author

Peissker, T. ; Gysbrechts, Barbara ; Fabris, Gloria ; Deschaume, Olivier ; Rand, Danielle R. ; Houben, Kelly ; Romero, Christian P. ; Van Bael, Margriet J. ; Bartic, Carmen

Author_Institution

Lab. of Solid State Phys. & Magn., KU Leuven, Leuven, Belgium

fYear

2012

Firstpage

1

Lastpage

4

Abstract

We present an approach to control the immobilization process of biomolecules by functionalization of SiO₂ substrates decorated with nanostructures. The creation of specific protein permissive and protein resistant areas leads to a directed and site-specific immobilization of proteins. We make use of molecular beam epitaxy and laser assisted cluster deposition to create Au nanostructures on PEG-silanized SiO₂ substrates. The chemical contrast provided by the two materials, namely Au and PEG on the substrate surface supports the specificity of thiol-based Au functionalization for biomolecule attachment.

Keywords

gold; molecular beam epitaxial growth; molecular biophysics; nanobiotechnology; nanopatterning; nanostructured materials; polymers; proteins; silicon compounds; Au; PEG silanized silica substrates; SiO₂; biomolecule immobilization process; chemical contrast; gold nanostructures; laser assisted cluster deposition; metal nanostructures; molecular beam epitaxy; site specific surface biofunctionalization; specific protein permissive areas; specific protein resistant areas; Crystals; Gold; Nanobioscience; Nanostructures; Proteins; Surfaces;

fLanguage

English

Publisher

ieee

Conference_Titel

Nanotechnology (IEEE-NANO), 2012 12th IEEE Conference on

Conference_Location

Birmingham

ISSN

1944-9399

Print_ISBN

978-1-4673-2198-3

Type

conf

DOI

10.1109/NANO.2012.6322185

Filename

6322185