Title :
Theory and Experiments of MEMS Thermal Biosensors
Author :
Wang, Li ; Lin, Qiao
Author_Institution :
Dept. of Mech. Eng., Carnegie Mellon Univ., Pittsburgh, PA
fDate :
6/27/1905 12:00:00 AM
Abstract :
This paper presents a theoretical and experimental investigation of MEMS thermal biosensors in flow-through measurements of metabolites. A model is developed to consider convective heat transfer effects and enzyme kinetics using the Michaelis-Menton theory. Numerical solutions from the model are compared with experimental data obtained from a prototype MEMS thermal biosensor. Satisfactory agreement is found between the theoretical and experimental results, indicating that the model is useful for designing MEMS thermal biosensors with optimized performance
Keywords :
bioMEMS; biochemistry; biosensors; biothermics; convection; enzymes; microfluidics; microsensors; molecular biophysics; temperature sensors; MEMS thermal biosensors; Michaelis-Menton theory; convective heat transfer effects; enzyme kinetics; flow-through measurements; metabolites; Biochemistry; Biomembranes; Biosensors; Heat transfer; Kinetic theory; Mechanical engineering; Micromechanical devices; Semiconductor device measurement; Sugar; Thermal conductivity;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1616665
