Title :
Representation, reasoning and the intermediary metabolism of Escherichia coli
Author_Institution :
Inst. for Biomed. Comput., Washington Univ. Sch. of Med., St. Louis, MO, USA
Abstract :
Computational methods of biological processes must express and use biological ideas as biologists do. The complexity of the biology and the flexible and elastic use of biological language offer significant problems in representing both information and reasoning. The author illustrates these problems and describes several strategies that can be used in designing representations. The approach to this class of problems is to develop accurate computational models of biological processes which can be verified by in vivo and in computo experimentation. The examples are drawn from efforts to study the cellular physiology of E. coli in computo using Prolog.
Keywords :
biology computing; cellular biophysics; Escherichia coli; Prolog; biological language; biological processes; cellular physiology; computational methods; computational models; intermediary metabolism; reasoning; Biochemistry; Biological processes; Biological system modeling; Biology computing; Biomedical computing; Cells (biology); Computational modeling; In vitro; In vivo; Organisms; Physiology;
Conference_Titel :
System Sciences, 1993, Proceeding of the Twenty-Sixth Hawaii International Conference on
Print_ISBN :
0-8186-3230-5
DOI :
10.1109/HICSS.1993.270605
