From bench to bedside with advanced confocal microendoscope

Author

Piyawattanametha, W. ; Mandella, M.J. ; Ra, H. ; Liu, J. T C ; Friedland, Shai ; Qiu, Zhen ; Kino, G.S. ; Wang, T.D. ; Contag, C.H. ; Solgaard, O.

Author_Institution

Dept. of Electr. Eng., Stanford Univ., Stanford, CA, USA

fYear

2010

Firstpage

83

Lastpage

84

Abstract

The authors have successfully demonstrated 3-D high-resolution real-time in vivo imaging by the miniature MEMS-scanner based DAC (dual-axes confocal) probes in both form-factors (10 and 5-mm diameter) by acquiring reflectance and fluorescence images. From the obtained high quality images, the DAC microscope shows great potential to substantially enhance clinical imaging practice by permitting sub-surface 3-D in vivo real-time imaging. When coupled with fluorescence markers targeted against a variety of diseases, the microscope will enable on-table-management with in vivo real-time optical biopsy for early and accurate detection of cancer resection.

Keywords

bioMEMS; biomedical optical imaging; cancer; endoscopes; optical microscopy; 3-D real-time imaging; DAC design; MEMS scanner based confocal endoscopic probe; cancer diagnosis; confocal microendoscope; dual-axes confocal microscope; gastrointestinal tract; gimbaled structure; human patients; imaging acquisition system; micromachined based DAC microscope-endoscope; photographs; prototype system; real-time image mosaicing; size 10 mm; size 5 mm; vertical-comb-actuators; Biomedical optical imaging; Diseases; Fluorescence; High-resolution imaging; In vivo; Optical coupling; Optical imaging; Optical microscopy; Probes; Reflectivity;

fLanguage

English

Publisher

ieee

Conference_Titel

Photonics Society Winter Topicals Meeting Series (WTM), 2010 IEEE

Conference_Location

Majorca

Print_ISBN

978-1-4244-5240-8

Electronic_ISBN

978-1-4244-5241-5

Type

conf

DOI

10.1109/PHOTWTM.2010.5421940

Filename

5421940