Title :
A combined haemodynamic and biochemical model of cerebral autoregulation
Author :
Payne, Stephen J. ; Morris, Henry J. ; Rowley, Alexander B.
Author_Institution :
Dept. of Eng. Sci., Oxford Univ.
Abstract :
The feedback processes that control the blood supply to the brain, collectively termed cerebral autoregulation, are many and complex. Failure of this mechanism is implicated in a number of conditions. However, in a clinical setting the number of variables that can be measured non-invasively is extremely limited. In addition, current models are either too crude, and not physiologically meaningful, or so complex that analysis is difficult. In this paper a new compact, but physiologically meaningful, model is presented, based on smooth muscle cells within a vessel model, integrated within a full haemodynamic model. Preliminary results show realistic behaviour
Keywords :
biochemistry; blood vessels; brain; cellular biophysics; haemodynamics; molecular biophysics; muscle; physiological models; biochemical model; brain blood supply; cerebral autoregulation; feedback processes; haemodynamic model; physiological model; smooth muscle cells; vessel model; Biomedical monitoring; Biomembranes; Blood flow; Calcium; Capacitance; Equations; Feedback; Muscles; Process control; Stress;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1616923
