Title :
Dynamics of FLT3 receptor under induced microwave stress
Author :
Bojovschi, A. ; Chu, Z. ; Rowe, W.S.T.
Author_Institution :
Electr. & Comput. Eng., RMIT Univ., Melbourne, VIC, Australia
Abstract :
The biological effect of electric fields on protein function and structure is a topic of increasing interest over the past few decades. With the proliferation of microwave devices the exposure to microwave radiation has become part of everyday life. The ubiquity of devices emitting electromagnetic radiation has highlighted concerns about the potential health effects. This work explores the dynamics of FLT3 under equilibrium conditions and under microwave stress. Equilibrium and non-equilibrium molecular dynamics are employed. The results show that intense microwave radiations can cause conformational changes in FLT3.
Keywords :
bioelectric phenomena; biological effects of microwaves; biomagnetism; biomolecular effects of radiation; enzymes; molecular dynamics method; FLT3 receptor dynamics; biological effect-of-electric fields; electromagnetic radiation; induced microwave stress; microwave devices; microwave radiation; nonequilibrium molecular dynamics; potential health effects; proliferation; protein function; protein structure; Electric fields; Electromagnetic heating; Force; Microwave oscillators; Proteins; Stress; FLT3; microwave stress; molecular dynamics; protein conformational changes;
Conference_Titel :
Microwave Conference Proceedings (APMC), 2011 Asia-Pacific
Conference_Location :
Melbourne, VIC
Print_ISBN :
978-1-4577-2034-5