Title :
Association of the spectral features of heart period signal with SNP of NOS in the Chinese Han nationality population
Author :
Ma, H.X. ; Niu, Y.H. ; Wang, Z.F. ; Li, Z.Y. ; Hua, M.J. ; Xie, Z.X.
Author_Institution :
Dept. of Geriatric, Chongqing Univ. of Med. Sci.
Abstract :
To explore association of the spectral features of heart period signal with SNPs at 5 sites of NOS gene in the subjects (male89, female77, aged 62.40+/-2.5 yrs) by allele specific primer PCR technique. It was found that the TT allelic genotype of NOS2 C-1173T associated with the highest RPH and TT allelic genotype of NOS3 G894T associated with the highest APH in HPS spectral parameters. This suggests the SNPs of NOS2 C-1173T and NOS3 G894T may be the deep layer factors to result in the variability of HPS spectral parameters
Keywords :
cellular biophysics; electrocardiography; genetics; molecular biophysics; polymorphism; 59.9 to 64.9 yr; Chinese Han nationality population; NOS gene; SNP; TT allelic genotype; allele specific primer PCR technique; heart period signal; spectral features; Biomedical engineering; Cardiac disease; DNA; Hafnium; Heart rate; Heart rate variability; Humans; Hypertension; Parasympathetic nervous system; Resonant frequency;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1616967
