A system theoretic study on an essential mechanism of generation of circadian oscillation

From the biological viewpoint, knowledge of the circadian rhythm has been accumulating due to a large amount of active research. The circadian rhythm has been still continuously investigated not only because it is vital to living organisms, but also it poses many unsolved problems. One of the problems is to locate dynamic components that are necessary for the generation of the persistent oscillation apart from the importance of materials in view of reaction and biological process. This paper attempts to provide an answer to the question by means of control systems theory.