Title :
Assessment of the HR baroreflex in human subjects using parametric system identification
Author :
Appel, Marvin L. ; Saul, J. Philip ; Berger, Ronald D. ; Cohen, Richard J.
Author_Institution :
Div. of Health & Sci. & Technol., Harvard-MIT, Cambridge, MA, USA
Abstract :
Quantitative assessment of the coupling between arterial blood pressure (ABP) and heart rate (HR) is discussed. Traditionally, the HR baroreflex has been studied directly by controlling sensed ABP independent of HR changes. A method is presented that, by combining broadband stimulation and parametric system identification, makes it possible to assess baroreceptor function without disturbing the normal closed-loop function of the cardiovascular system. Preliminary results suggest that the methodology can detect changes in baroreceptor sensitivity in response to the administration of atropine and propanolol
Keywords :
cardiology; haemodynamics; parameter estimation; arterial blood pressure; atropine; broadband stimulation; cardiovascular system; closed-loop function; heart rate baroreflex; parametric system identification; propanolol; Arterial blood pressure; Baroreflex; Cardiovascular system; Data analysis; Feedback; Fluctuations; Heart rate; Humans; Protocols; System identification;
Conference_Titel :
Engineering in Medicine and Biology Society, 1989. Images of the Twenty-First Century., Proceedings of the Annual International Conference of the IEEE Engineering in
Conference_Location :
Seattle, WA
DOI :
10.1109/IEMBS.1989.95599
