DocumentCode
1640521
Title
Motifs in regulatory networks and their structural robustness
Author
Elena, A. ; Ben-Amor, H. ; Glade, N. ; Demongeot, J.
Author_Institution
TIMC-IMAG, Univ. J. Fourier, Grenoble
fYear
2008
Firstpage
1
Lastpage
6
Abstract
If we consider the regulatory networks used in systems biology (especially in neural and genetic networks), we observe certain regularities in their architecture, namely the occurrence of interaction motifs, i.e. of oriented sub-graphs relating their elements with the same interaction scheme. We propose here to describe some of these motifs we can consider as universal because they are often met in the regulatory networks architecture, and to study their main robustness properties (called also structural stability), i.e. their ability to keep after topological or dynamical perturbations, their essential asymptotic features, as their attractors number, shape and behaviour, like their periodicity.
Keywords
cellular biophysics; genetics; network theory (graphs); network topology; neural nets; neurophysiology; attractor number; genetic regulatory networks; interaction motifs; network architecture; network asymptotic features; network behaviour; network dynamical perturbations; network motif structure robustness; network periodicity; network shape; network structural stability; network topological perturbations; neural networks; oriented subgraphs; regulatory network motif; systems biology; Electronic mail; Genetic expression; Jacobian matrices; Neurons; Organisms; Robust stability; Robustness; Shape; Structural engineering; Systems biology; attractors; interaction motifs; periodicity; regulatory networks; robustness; structural stability;
fLanguage
English
Publisher
ieee
Conference_Titel
BioInformatics and BioEngineering, 2008. BIBE 2008. 8th IEEE International Conference on
Conference_Location
Athens
Print_ISBN
978-1-4244-2844-1
Electronic_ISBN
978-1-4244-2845-8
Type
conf
DOI
10.1109/BIBE.2008.4696699
Filename
4696699
Link To Document