• DocumentCode
    1640521
  • Title

    Motifs in regulatory networks and their structural robustness

  • Author

    Elena, A. ; Ben-Amor, H. ; Glade, N. ; Demongeot, J.

  • Author_Institution
    TIMC-IMAG, Univ. J. Fourier, Grenoble
  • fYear
    2008
  • Firstpage
    1
  • Lastpage
    6
  • Abstract
    If we consider the regulatory networks used in systems biology (especially in neural and genetic networks), we observe certain regularities in their architecture, namely the occurrence of interaction motifs, i.e. of oriented sub-graphs relating their elements with the same interaction scheme. We propose here to describe some of these motifs we can consider as universal because they are often met in the regulatory networks architecture, and to study their main robustness properties (called also structural stability), i.e. their ability to keep after topological or dynamical perturbations, their essential asymptotic features, as their attractors number, shape and behaviour, like their periodicity.
  • Keywords
    cellular biophysics; genetics; network theory (graphs); network topology; neural nets; neurophysiology; attractor number; genetic regulatory networks; interaction motifs; network architecture; network asymptotic features; network behaviour; network dynamical perturbations; network motif structure robustness; network periodicity; network shape; network structural stability; network topological perturbations; neural networks; oriented subgraphs; regulatory network motif; systems biology; Electronic mail; Genetic expression; Jacobian matrices; Neurons; Organisms; Robust stability; Robustness; Shape; Structural engineering; Systems biology; attractors; interaction motifs; periodicity; regulatory networks; robustness; structural stability;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    BioInformatics and BioEngineering, 2008. BIBE 2008. 8th IEEE International Conference on
  • Conference_Location
    Athens
  • Print_ISBN
    978-1-4244-2844-1
  • Electronic_ISBN
    978-1-4244-2845-8
  • Type

    conf

  • DOI
    10.1109/BIBE.2008.4696699
  • Filename
    4696699