Title :
A computer simulation model of gene replacement in vector populations
Author :
Guevara, Mauricio ; Vallejo, Edgar E.
Author_Institution :
Comput. Sci. Dept., ITESM, Zaragoza
Abstract :
In this paper, we conduct a series of computer simulations on the genetic modification of disease vectors. In our model, a population of mosquitoes is modeled as DNA sequences. A gene drive mechanism based on simulated transposable elements is inserted into DNA sequences to confer immunity to individuals. Different scenarios on the spread and prevalence of modified genes are simulated using the evolutionary game theory. Preliminary results suggest that the proposed model could be useful for identifying a set of population-level conditions that a disease control strategy based on genetic modification of vectors should satisfy to be effective.
Keywords :
DNA; bioinformatics; diseases; game theory; genetics; molecular biophysics; DNA sequence; disease control strategy; disease vectors; evolutionary game theory; gene drive mechanism; gene replacement; genetic modification; modified gene prevalence; modified gene spread; mosquitoes; vector population; Capacitive sensors; Computational modeling; Computer simulation; DNA; Game theory; Genetics; Immune system; Parasitic diseases; Sequences; Strain control;
Conference_Titel :
BioInformatics and BioEngineering, 2008. BIBE 2008. 8th IEEE International Conference on
Conference_Location :
Athens
Print_ISBN :
978-1-4244-2844-1
Electronic_ISBN :
978-1-4244-2845-8
DOI :
10.1109/BIBE.2008.4696743
