DocumentCode :
1643235
Title :
Local hemodynamics and intimal hyperplasia at the venous side of porcine carotid artery - Jugular vein shunt
Author :
Manos, Themistoklis A. ; Sokolis, Dimitrios P. ; Giagini, Athina T. ; Davos, Constantinos H. ; Kakisis, John D. ; Stergiopulos, Nikos ; Karayannacos, Panayotis E. ; Tsangaris, Sokrates
Author_Institution :
Lab. of Biofluid-Mech. & Biomed. Eng., Nat. Tech. Univ. of Athens, Athens
fYear :
2008
Firstpage :
1
Lastpage :
8
Abstract :
One of the chief factors, incriminated for the formation of intimal hyperplasia at the venous side of an arteriovenous shunt (AVS), is the disturbed hemodynamic condition in that region. Owing to the difficulty of properly measuring the local flow field in AVS, numerical computation has been extensively used for its assessment. The purpose of this study was to examine the flow field in AVS with computational fluid dynamics (CFD). AVS was created in a pig between the common carotid artery and the internal jugular vein using an ePTFE graft. Input data to the computational model was obtained in vivo one month later, and adjacent vessels were excised and submitted to histological examination. The 3D geometry of the shunt was determined using biplane angiography. Ultrasound measurements of the flow rates were performed with perivascular flow probes. Pressures were recorded using intravascular catheters. This data was used as boundary conditions in the commercial code FLUENTreg for calculation of the flow field. Our numerical findings are suggestive of strong Dean vortices towards both vein flow exits, verified by color Doppler. The high wall shear stresses that accompany these vortices are related to areas of intimal hyperplasia, as evidenced in preliminary histological studies of the venous vessel wall.
Keywords :
Doppler measurement; angiocardiography; biomedical ultrasonics; blood flow measurement; blood pressure measurement; blood vessels; cardiovascular system; computational fluid dynamics; prosthetics; 3D shunt geometry; Dean vortices; arteriovenous shunt; biplane angiography; color Doppler; commercial code FLUENT; computational fluid dynamics; internal jugular vein; intimal hyperplasia; intravascular catheters; local hemodynamics; perivascular flow probes; polytetrafluroethylene graft; porcine carotid artery; pressure measurements; shear stresses; ultrasound measurements; Angiography; Carotid arteries; Computational fluid dynamics; Computational modeling; Fluid flow measurement; Geometry; Hemodynamics; In vivo; Ultrasonic imaging; Veins;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
BioInformatics and BioEngineering, 2008. BIBE 2008. 8th IEEE International Conference on
Conference_Location :
Athens
Print_ISBN :
978-1-4244-2844-1
Electronic_ISBN :
978-1-4244-2845-8
Type :
conf
DOI :
10.1109/BIBE.2008.4696814
Filename :
4696814
Link To Document :
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