Chemical stimulation of Aplysia californica ganglion with microfluidic signal generators

Author

Azizi, Farouk ; Mastrangelo, Carlos H. ; Lu, Hui ; Chiel, Hillel J.

Author_Institution

Depts. of Electr. & Biomed. Eng., Univ. of Utah, Salt Lake City, UT

fYear

2008

Firstpage

305

Lastpage

308

Abstract

We implemented a microfluidic signal generator chip for the in-vitro study of the nervous system of Aplysia californica under localized chemical stimulation. The PDMS chip implements a one-bit pulse-code modulator that digitally controls the concentration of the non-hydrolysable cholinergic agonist carbachol injected directly above a ganglion. The chip was successful in inducing a burst of ingestive patterns.

Keywords

bioMEMS; biochemistry; biomedical electronics; digital control; lab-on-a-chip; medical control systems; microfluidics; neurophysiology; pulse code modulation; signal generators; Aplysia californica ganglion; PDMS chip; carbachol injection; digital control; in-vitro study; ingestive patterns; localized chemical stimulation; microfluidic signal generator chip; nervous system; nonhydrolysable cholinergic agonist; one-bit pulse-code modulator; Chemicals; Frequency; Microfluidics; Nervous system; Phase change materials; Plugs; Pulse modulation; Signal generators; Solvents; Valves;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Circuits and Systems Conference, 2008. BioCAS 2008. IEEE

Conference_Location

Baltimore, MD

Print_ISBN

978-1-4244-2878-6

Electronic_ISBN

978-1-4244-2879-3

Type

conf

DOI

10.1109/BIOCAS.2008.4696935

Filename

4696935