CMOS image sensor for recording of intrinsic-optical-signal of the brain

Intrinsic optical signal (IOS) indicates activities of cerebral cortical neurons in the optical imaging method, which is one of the in vivo recording methods of activities of cerebral cortical neurons. We propose the IOS imaging method for craniotomy procedure such as diagnostic use of epilepsy surgery. We designed a prototype CMOS image sensor device using 0.35-¿m CMOS standard process for in vivo IOS imaging. The sensor device enables multi-functional recording of brain activities such as IOS, EEG, area image, electrical stimulation in order to improve reliability of diagnosis and allows simple measurement setup. Preliminary experiments using the fabricated device are demonstrated to detect hemoglobin filled in a blood vessel phantom.