Title :
A model for blood-tissue oxygen exchange and tracer water production
Author :
Mates-Needham, E.A. ; Bassingthwaighte, James B.
Author_Institution :
Center for Bioeng., Washington Univ., Seattle, WA, USA
Abstract :
An axially distributed three-region multibarrier model was formulated for oxygen transport and metabolism in a generic capillary-tissue system. The model considers blood flow through arterial, capillary, and venular vessels, countercurrent solute exchange between arteriole and venule, differences in erythrocyte and plasma velocities, and differences in effective volumes of distribution for water versus oxygen. The formulation therefore incorporates higher velocity for RBCs compared to plasma. Additionally, because of the high affinity of O2 to hemoglobin, the relative volume of distribution in blood compared to tissue is much higher for O2 than for H2O and the O2 transit time is much less than that for H2O. It was found that under conditions of high-permeability surface area, there are dramatic changes in the profiles of both O2 and H2O outflow curves with changes in O2 consumption rates. The implications of these observations with respect to oxygen delivery to hypoxic tissues are discussed
Keywords :
biorheology; biotransport; blood; oxygen; physiological models; H2O; O2; arteriole; axially distributed 3-region multibarrier model; countercurrent solute exchange; erythrocyte velocity; generic capillary-tissue system; plasma velocity; venule; Arteries; Biochemistry; Biomedical engineering; Blood flow; Cells (biology); Lipidomics; Oxygen; Permeability; Plasma transport processes; Production;
Conference_Titel :
Engineering in Medicine and Biology Society, 1989. Images of the Twenty-First Century., Proceedings of the Annual International Conference of the IEEE Engineering in
Conference_Location :
Seattle, WA
DOI :
10.1109/IEMBS.1989.95709
