Closed-loop control of multiple drug infusions

An original approach for the development of a closed-loop system for the adjustment of drug and fluid infusions has been investigated. The approach, based on expert system techniques, resulted in a system with a high level of clinical utility and which exhibited robust control characteristics. This work represents the first known clinical application of a closed-loop system for the control of multiple drug and fluid infusions. Current attention is focused on the incorporation of a Doppler device for continuous monitoring of cardiac output into this system