Highly sensitive and selective label-free detection of cardiac biomarkers in blood serum with silicon nanowire biosensors

Author

Zhang, Guo-Jun ; Luo, Zhan Hong Henry ; Huang, Min Joon ; Tay, Guang Kai Ignatius ; Lim, Eu-Jin Andy ; Chen, Yu

Author_Institution

Inst. of Microelectron., A*STAR (Agency for Sci., Technol. & Res.), Singapore, Singapore

fYear

2009

Firstpage

1

Lastpage

4

Abstract

Arrays of highly ordered silicon nanowire (SiNW) are fabricated using complementary metal-oxide semiconductor (CMOS) field effect transistor-compatible technology, and the ultrasensitive, label-free, electrical detection of cardiac biomarker in blood serum using the array sensor is demonstrated. The SiNW array biosensor allows for real-time detection of cardiac biomarker in desalted serum, more importantly, multiplexed detection of cardiac biomarkers in untreated and non-desalted blood serum.

Keywords

CMOS integrated circuits; biosensors; cardiology; detector circuits; elemental semiconductors; nanowires; silicon; CMOS technology; Si; cardiac biomarker; complementary metal oxide semiconductor field effect transistor; desalted serum; nondesalted blood serum; selective label-free detection; silicon nanowire biosensors; Biomarkers; Biosensors; Blood; Nanobioscience; Nanoscale devices; Optical sensors; Sensor arrays; Silicon; Surface resistance; Surface treatment;

fLanguage

English

Publisher

ieee

Conference_Titel

Electron Devices Meeting (IEDM), 2009 IEEE International

Conference_Location

Baltimore, MD

Print_ISBN

978-1-4244-5639-0

Electronic_ISBN

978-1-4244-5640-6

Type

conf

DOI

10.1109/IEDM.2009.5424265

Filename

5424265