Title :
Highly sensitive and selective label-free detection of cardiac biomarkers in blood serum with silicon nanowire biosensors
Author :
Zhang, Guo-Jun ; Luo, Zhan Hong Henry ; Huang, Min Joon ; Tay, Guang Kai Ignatius ; Lim, Eu-Jin Andy ; Chen, Yu
Author_Institution :
Inst. of Microelectron., A*STAR (Agency for Sci., Technol. & Res.), Singapore, Singapore
Abstract :
Arrays of highly ordered silicon nanowire (SiNW) are fabricated using complementary metal-oxide semiconductor (CMOS) field effect transistor-compatible technology, and the ultrasensitive, label-free, electrical detection of cardiac biomarker in blood serum using the array sensor is demonstrated. The SiNW array biosensor allows for real-time detection of cardiac biomarker in desalted serum, more importantly, multiplexed detection of cardiac biomarkers in untreated and non-desalted blood serum.
Keywords :
CMOS integrated circuits; biosensors; cardiology; detector circuits; elemental semiconductors; nanowires; silicon; CMOS technology; Si; cardiac biomarker; complementary metal oxide semiconductor field effect transistor; desalted serum; nondesalted blood serum; selective label-free detection; silicon nanowire biosensors; Biomarkers; Biosensors; Blood; Nanobioscience; Nanoscale devices; Optical sensors; Sensor arrays; Silicon; Surface resistance; Surface treatment;
Conference_Titel :
Electron Devices Meeting (IEDM), 2009 IEEE International
Conference_Location :
Baltimore, MD
Print_ISBN :
978-1-4244-5639-0
Electronic_ISBN :
978-1-4244-5640-6
DOI :
10.1109/IEDM.2009.5424265
