Title :
A mathematical study of the relationship between cerebral blood volume and intracranial pressure changes
Author :
Ursino, Mauro ; Di Giammarco, Patrieia
Abstract :
Some preliminary results obtained with an original mathematical model of human intracranial dynamics are presented. The aim of the work is to gain deeper insight into the relationship between intracranial pressure, cerebral blood volume, and the action of cerebrovascular regulatory mechanisms. In building the model, dynamics of brain tissue, cerebrospinal fluid, cerebral veins and intracranial arterial vessels have been reproduced according to physiological considerations. Moreover, two different kinds of feedback regulatory mechanism have been assumed to operate on proximal arteries and arterioles. Results of the simulation show that, when the craniospinal compartment is more rigid than normal, vasodilation of cerebral vessels induced by autoregulatory adjustments can cause significant fluctuations in the intracranial pressure
Keywords :
brain models; haemodynamics; brain tissue; cerebral blood volume; cerebral veins; cerebrospinal fluid; cerebrovascular regulatory mechanisms; feedback regulatory mechanism; human intracranial dynamics; intracranial arterial vessels; intracranial pressure changes; mathematical model; vasodilation; Arteries; Blood; Brain modeling; Cranial pressure; Feedback; Fluctuations; Fluid dynamics; Humans; Mathematical model; Veins;
Conference_Titel :
Engineering in Medicine and Biology Society, 1989. Images of the Twenty-First Century., Proceedings of the Annual International Conference of the IEEE Engineering in
Conference_Location :
Seattle, WA
DOI :
10.1109/IEMBS.1989.95732
